Targeting FGFR

  • Fibroblast growth factor (FGF) receptors (FGFR1, FGFR2, FGFR3, and FGFR4) are receptor tyrosine kinases involved in cell proliferation, cell differentiation, cell migration, and cell survival1
  • FGFR genetic alterations have been implicated as oncogenic drivers in a variety of tumor types. Some examples of these genetic alterations are FGFR gene amplifications, activating mutations, and chromosomal translocations2,3
  • Therapeutic targeting of FGFRs implicated in oncogenesis is a major area of drug development research4

Learn about FGFRs

QED Pipeline

Clinical Trials Currently Enrolling*

PROPEL logo

An observational research study designed to learn more about the overall health, growth, and possible medical complications in children with achondroplasia (a bone growth disorder). No medication will be administered; however, children successfully enrolled in PROPEL for 6 months or more may be eligible for subsequent treatment trials sponsored by QED Therapeutics, including PROPEL 2.

References

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  2. Turner N et al. Nat Rev Cancer. 2010;10:116-129.
  3. Katoh M. Nat Rev Clin Oncol. 2019;16:105-122.
  4. Babina IS et al. Nat Rev Cancer. 2017;17:318-332.
  5. TRUSELTIQ Prescribing Information. Brisbane, CA: QED Therapeutics, Inc.; [Month] 2021.
  6. American Cancer Society. https://www.cancer.org/cancer/bile-duct-cancer/about/key-statistics. Accessed March 27, 2021.
  7. Lamarca A et al. J Clin Med. 2020;9(9):2854.
  8. Arai Y et al. Hepatology. 2014;59(4):1427-1434.
  9. Kongpetch S et al. JCO Global Oncol. 2020;6:628-638.
  1. Ross JS et al. Cancer. 2016;122(5):702-711.
  2. Sfakianos JP et al. Eur Urol. 2015;68(6):970-977.
  3. Moss TJ et al. Eur Urol. 2017;72(4):641-649.
  4. Bagrodia A et al. J Urol. 2016;195(6):1684-1689.
  5. Bagrodia A et al. Eur Urol Focus. 2019;5(3):365-368.
  6. Audenet F et al. Clin Cancer Res. 2019;25(3):967-976.
  7. Komla-Ebri D et al. J Clin Invest. 2016;126(5):1871-1884.
  8. National Institutes of Health. https://ghr.nlm.nih.gov/condition/achondroplasia. Accessed April 1, 2021.
  9. Legare JM et al. https://www.ncbi.nlm.nih.gov/books/NBK1152/. Accessed April 1, 2021.