Targeting FGFR
- Fibroblast growth factor (FGF) receptors (FGFR1, FGFR2, FGFR3, and FGFR4) are receptor tyrosine kinases involved in cell proliferation, cell differentiation, cell migration, and cell survival1
- FGFR genetic alterations have been implicated as oncogenic drivers in a variety of tumor types. Some examples of these genetic alterations are FGFR gene amplifications, activating mutations, and chromosomal translocations2,3
- Therapeutic targeting of FGFRs implicated in oncogenesis is a major area of drug development research4