Fibroblast growth factor (FGF) receptors (FGFR1, FGFR2, FGFR3, and FGFR4) are receptor tyrosine kinases involved in cell proliferation, cell differentiation, cell migration, and cell survival1
FGFR genetic alterations have been implicated as oncogenic drivers in a variety of tumor types. Some examples of these genetic alterations are FGFR gene amplifications, activating mutations, and chromosomal translocations2,3
Therapeutic targeting of FGFRs implicated in oncogenesis is a major area of drug development research4
The PROOF Trial is a Phase 3 trial evaluating oral infigratinib vs gemcitabine + cisplatin in first-line, FGFR2 fusion-positive CCA. Patients are randomized 2:1 to receive investigational, oral infigratinib 125 mg once daily for the first 3 weeks (21 days) OR gemcitabine with cisplatin on Days 1 and 8 of a 21-day cycle.
The PROOF 302 Trial is a Phase 3, multicenter, double-blind, randomized, placebo-controlled trial of infigratinib for the adjuvant treatment of subjects with invasive urothelial carcinoma with FGFR3 genomic alterations.
Subjects will be randomized in a 1:1 ratio to receive oral infigratinib or placebo, administered once daily for the first 3 weeks (21 days) of a 28-day treatment cycle for a maximum of 52 weeks.
An observational research study designed to learn more about the overall health, growth, and possible medical complications in children with achondroplasia (a bone growth disorder). No medication will be administered; however, children successfully enrolled in PROPEL for 6 months or more may be eligible for subsequent treatment trials sponsored by QED Therapeutics, including PROPEL 2.
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